β-arrestins and G protein-coupled receptor kinases in viral entry: A graphical reviewReview Published on 2023-02-012023-07-11 Journal: Cellular signalling [Category] COVID19(2023년), [키워드] B-arrestin clathrin endocytosis Filovirus flavivirus G protein GPCR GRK Influenza virus Polyomavirus Signaling virus. [DOI] 10.1016/j.cellsig.2022.110558 PMC 바로가기 [Article Type] Review
SARS-CoV-2 pseudovirus enters the host cells through spike protein-CD147 in an Arf6-dependent mannerSARS-CoV-2 슈도바이러스는 Arf6 의존적 방식으로 스파이크 단백질-CD147을 통해 숙주 세포에 들어갑니다.Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approach Arf6 blockade CD147 cells clathrin Clathrin-mediated endocytosis clinically coronavirus endocytic endocytic mechanism endocytosis evaluate feasible function host cell host cells Huh-7 cell Huh-7 cells independent independent of indicated infected Vero E6 cells Infection inhibited inhibitor knockdown Localization macropinocytosis pathway Prevent pseudovirus pseudovirus infection public health RAB5A SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 pseudovirus SARS-CoV-2 pseudovirus infection severe acute respiratory syndrome Coronavirus Spike protein spike protein. Spread the SARS-CoV-2 variant Vero E6 VERO E6 cells viral infection weakened [DOI] 10.1080/22221751.2022.2059403 PMC 바로가기 [Article Type] Article
Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection게놈 전체에 걸친 양방향 CRISPR 스크린은 뮤신을 SARS-CoV-2 감염을 조절하는 숙주 인자로 식별합니다Article Published on 2022-08-012022-09-11 Journal: Nature Genetics [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술, 치료법, 치료제, [키워드] ACE2 Activation acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus airway Antiviral bidirectional cause clathrin conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 CRISPR CRISPR screen Critical Defense defense mechanism Epigenetic epithelial cell epithelial cells expression Factor family functional highlight Highlights Host host defense human lung human lung epithelial cells identify in vitro infected individuals Infection inflammatory signaling inhibit mechanism mild respiratory modulating molecular weight mucin mucins murine models Pathways progression provide Regulation respiratory respiratory distress Respiratory illness respiratory viruses SARS-CoV-2 SARS-CoV-2 entry factors SARS-COV-2 infection SARS-CoV-2-host interaction SARS-CoV-2-host interactions severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 starting point Symptom syndrome the SARS-CoV-2 TMPRSS2 transcriptional Transport Viral viral infection [DOI] 10.1038/s41588-022-01131-x PMC 바로가기 [Article Type] Article
Structural similarity-based prediction of host factors associated with SARS-CoV-2 infection and pathogenesisSARS-CoV-2 감염 및 발병과 관련된 숙주 인자의 구조적 유사성 기반 예측Article Published on 2022-08-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 유전자 메커니즘, [키워드] Analysis Apoptosis axon guidance CASP3 CD4 CD4 degradation clathrin Clathrin-mediated endocytosis clathrin-mediated endocytosis. composed Degradation down-regulate eIF2a Endoplasmic reticulum endosome enriched pathway enrichment analysis ERGIC event Factor Factors Genome heme HOPS complex Host information inhibitor interferon IRF1 life cycle matrix protein mechanism medical intervention membrane occur organized pandemic Pathogenesis phosphorylate predicted proteasomal degradation Protein protein kinase protein-protein interaction public health replicate reveal RNA synthesis SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 life cycle Signaling similarity T cell therapeutic intervention TP53 translational Transport UBA52 UBC Vesicle viral entry viral pathogenesis Viral protein virion assembly Virus life cycle [DOI] 10.1080/07391102.2021.1874532 PMC 바로가기 [Article Type] Article
Biodistribution and Cellular Internalization of Inactivated SARS-CoV-2 in Wild-Type Mice야생형 마우스에서 비활성화된 SARS-CoV-2의 생체분포 및 세포 내재화Article Published on 2022-07-092022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACE2 ACE2 receptors administration analyzed angiotensin attachment Brain can not caveolin cell entry receptor cell line cellular cellular uptake clathrin Consensus conserved expression heart help heparan sulfate heparan sulfate proteoglycans heparin human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 in vitro in vivo inactivated infected with SARS-CoV-2 Inflammation internalization intravenous Intravenous administration mammalian mice molecular interaction motif mouse Muridae murine organ Proteoglycan raised reported SARS-CoV-2 SARS-CoV-2 particle SARS-CoV-2 receptors Spike protein sulfate syndecan syndecan-4 syndecans syndecans. tissue TNF-α transmembrane various tissues wild-type [DOI] 10.3390/ijms23147609 PMC 바로가기 [Article Type] Article
Cytoplasmic domain and enzymatic activity of ACE2 are not required for PI4KB dependent endocytosis entry of SARS-CoV-2 into host cellsSARS-CoV-2의 숙주 세포 내로의 PI4KB 의존성 세포내이입 진입에는 ACE2의 세포질 도메인 및 효소 활성이 필요하지 않습니다Article Published on 2022-06-012022-09-11 Journal: Virologica Sinica [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 addition angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 Angiotensin converting enzyme 2 (ACE2) catalytic activity causative agent Cell cellular cellular entry cellular receptor clathrin Clathrin-mediated endocytosis COVID-19 pandemic delta variant demonstrated dependent on domain effective endocytosis entry of SARS-CoV-2 enzymatic activity enzyme health emergency host cell host cells human angiotensin converting enzyme 2 infections intracellular domain lentivirus Phosphoinositides PI4KB predominant principle pseudotype required SARS-CoV-2 Spike protein syncytium syncytium formation Syncytium. treat variant viral entry virus entry [DOI] 10.1016/j.virs.2022.03.003 PMC 바로가기 [Article Type] Article
Genome-wide CRISPR screens identify GATA6 as a proviral host factor for SARS-CoV-2 via modulation of ACE2게놈 전체의 CRISPR 화면은 ACE2의 변조를 통해 GATA6을 SARS-CoV-2의 프로바이러스 숙주 인자로 식별합니다.Article Published on 2022-04-252022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 신약개발, 유전자 메커니즘, 치료제, [키워드] ACE2 Alpha Alpha variant Analysis anti-SARS-CoV-2 Beta biogenesis candidate cellular clathrin clinical sample clinical samples collected Comparative analysis component COVID-19 pathogenesis CRISPR CRISPR screen Critical data-set elevated facilitate Factor GATA6 Health heparan sulfate Host host gene host genes identify infected individuals Infection KREMEN2 list loss-of-function modulation pathway pharmacological phosphatidylglycerol regulate required SARS-CoV-2 SARS-CoV-2 cell SARS-CoV-2 infected individual SARS-CoV-2 infected individuals SARS-COV-2 infection SETDB1 Spread sulfate target therapeutic interventions therapeutic strategy Transcription transcription factor Transport unique variant variants of concern variants of SARS-CoV-2 viral infectivity virus pathogenesis VoC VOCs wild type Zinc [DOI] 10.1038/s41467-022-29896-z PMC 바로가기 [Article Type] Article
Case Report: Precision COVID-19 Immunization Strategy to Overcome Individual Fragility: A Case of Generalized Lipodystrophy Type 4증례보고: 개인의 취약성을 극복하기 위한 정밀 코로나19 예방접종 전략: 전신성 지방이영양증 4형 1예Case Reports Published on 2022-04-062022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] Ad26 Adenovirus administration affected biallelic variant biallelic variants BNT162b2 BNT162b2 vaccine Case report caused CAVIN1 clathrin congenital generalized lipodystrophy type 4 controls COVID-19 dose Generalized Health care individual Interaction Lipodystrophy memory B cell memory B cells memory B cells. molecule mRNA occur Patient RBD-specific antibodies RBD-specific antibody receptor Regulation respond SARS-CoV-2 SARS-CoV-2 vaccine significantly single dose specific antibodies Strategy the disease Transport Type vaccination Vaccine worker [DOI] 10.3389/fimmu.2022.869042 PMC 바로가기 [Article Type] Case Reports
SARS-CoV-2 Infects Human ACE2-Negative Endothelial Cells through an α v β 3 Integrin-Mediated Endocytosis Even in the Presence of Vaccine-Elicited Neutralizing AntibodiesSARS-CoV-2는 백신 유도 중화 항체가 있는 경우에도 α v β 3 인테그린 매개 세포내이입을 통해 인간 ACE2 음성 내피 세포를 감염시킵니다Article Published on 2022-03-292022-09-11 Journal: Viruses [Category] MERS, SARS, 변종, 진단, [키워드] absence ACE2 acute respiratory syndrome Angiogenesis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anti-spike antibodies antibody BNT162b2 BNT162b2 vaccine Cell clathrin conserved endocytosis Endothelial cell endothelial cell dysfunction endothelial cells enzyme Evidence expression functional gateway highlight Human human lung impair Infection inhibit SARS-CoV-2 integrin integrin-mediated Integrins Interaction Intervention Lineage maintain monoclonal antibody motif neutralize phenotype Presence Prevent productive viral replication promote Protein RBD Receptor binding domain respiratory responsible RGD motif SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 variants sequence Spike protein the SARS-CoV-2 the Spike the vaccine vaccination Viral viral envelope virus virus viruses αvβ3 integrin αvβ3 integrin. [DOI] 10.3390/v14040705 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Infectivity and Neurological Targets in the Brain뇌의 SARS-CoV-2 감염성과 신경학적 표적Article Published on 2022-01-012022-09-11 Journal: Cellular and molecular neurobiology [Category] 유전자 메커니즘, 치료법, [키워드] ACE2 ACE2 expression acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alzheimer’s disease analyzed angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Angiotensin-converting enzyme 2 (ACE2) receptor Brain brain regions Brainstem cause Cell cell types cells cerebral cortex clathrin controls coronavirus coronavirus disease Coronavirus disease 2019 CoV-19 COVID-19 digestive endocytic pathways enzyme explain expressed fetal gateway Hartnup's disease highest Host human host cell human host cells human tissue immune Infectivity Invasion mechanism Medulla oblongata microRNA miRNA miRNA-5197 oblongata organ system organ systems pathway Pathways Patient patients pons receptor reproductive respiratory distress RNA SARS-CoV-2 SARS-COV-2 infection Severe respiratory distress severity Signs and symptoms single stranded RNA (ssRNA). ssRNA susceptibility Symptom target tissue tissues transmembrane variety weakness [DOI] 10.1007/s10571-020-00947-7 PMC 바로가기 [Article Type] Article